a Record control number WOS:000297658400013

a ISSN 0008-8749

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QU 300

b Item number .E34 2011

a Personal name V. Nimet, Izgut-Uysal.

h Medium Electronic Document

a Title Effect of orexin-A on phagocytic activity of peritoneal macrophage in starved rats

c Statement of responsibility, etc V. Nimet, Izgut-Uysal, Burcu Gemici, Ruken Tan.

a Place of publication, distribution, etc Academic Press Inc Elsevier Science,

c Date of publication, distribution, etc 2011.

a Summary, etc The aim of this study was to investigate the effect of fasting-induced orexin-A (OXA) on inflammation and macrophage phagocytic activity. Fifty six male wistar rats were fasted for 36 h to stimulate OXA synthesis. In 24 rats, air pouches were induced subcutaneously in the intrascapular area. After (6 h) carrageenan injection into the pouches, the contents of the air pouches were removed. The exudate volume, protein content and cell count were measured. After the determination of fasting on inflammation, the peritoneal macrophages were collected from 32 rats to investigate the effect of fasting-induced OXA on macrophage phagocytic activity. Plasma OXA levels were markedly higher in fasted rats compared with control rats. The phagocytic capability of peritoneal macrophages was obtained as a percentage of phagocytosing macrophages and number of phagocytosed particles per cell. In spite of increased blood OXA level SB-334867, selective orexin type 1 receptor antagonist (10 mg/kg) did not change phagocytic activity of peritoneal macrophages. These findings indicate that 36 h fasting-induced OXA has no significant effect to phagocytosis of peritoneal macrophages. (C) 2011 Elsevier Inc. All rights reserved.

a Topical term or geographic name as entry element Cell Biology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Phagocytic activity

a Topical term or geographic name as entry element Macrophages

a Topical term or geographic name as entry element Orexin-A

g Relationship information 2011, Vol 271 Issue 1, p85-88

x International Standard Serial Number 00088749

t Title Cellular Immunology

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1016/j.cellimm.2011.06.005